Biofuels That Look Like Gasoline

The offspring of Jay Keasling’s synthetic biology research and vision, Emeryville, CA-based Amyris Biotechnologies has made a double impact. First, the company, with more than $40 million of backing from the Bill Gates’ Institute for One World Health charity, developed a microbial route to the anti-malarial compound artemisinin. In and of itself this work was a stunningly successful scientific achievement, and the resulting process has been licensed to Sanofi-Aventis for low-cost manufacturing and distribution in the third world.

But how does that relate to biofuels? Well, producing the anti-malarial drug relied on the engineering of a metabolic pathway to produce a key intermediate that is in the class of chemicals called terpenes. Chemically, terpenes are hydrocarbons, similar to diesel or gasoline, and are therefore very good fuel compounds. Thus, the same basic science that led to artemisinin can be applied, with appropriate tweaking, to produce fuels based on terpenes. And according to the company, a desired fuel compound can be selected based on its properties (flash point, cloud point, boiling point, density, fuel value, etc), and then the pathway to produce it can be designed. Voila! You have a designer fuel. And being hydrocarbons with properties similar to gasoline, terpenes do not suffer from the limitations that alcohols (particularly ethanol) have as fuels. If you want to put something into your gas tank or jet engine, a designer hydrocarbon is likely to be superior to any alcohol. At least that is what Amyris argues.

Amyris has the backing of a well-heeled group of VCs: Kleiner Perkins, TPG Biotech, and DAG Ventures. In the area of bio-based production of gasoline-like fuels, Amyris is at the head of the class. Economics remain to be proven, but Amyris has formed a joint venture with the second largest Brazilian sugar producer, Crystalsev, to get access to inexpensive sugar feedstock, and the first demonstration plant is scheduled to be built right on the sugar plantation in Brazil by 2010. It will produce a biodiesel (with the interesting name of “No CompromiseTM”), currently being piloted at Amyris’ Emerville facility. Amyris promises that a bio-gasoline and a bio-aviation fuel are not far behind. If any company can make terpene-based fuels successfully, Amyris appears to be that company.